Proteiny lidské plasmy tvoří rozsáhlou skupinu proteinů. Můžeme je rozdělit do 5 skupin: albuminy, α 1 -globuliny, α 2 -globuliny, β -globuliny a μ -globuliny. Dělení plasmatických proteinů pomocí elektroforesy je cenným diagnostickým nástrojem. Pro stanovení těchto proteinů jsou využívány imunochemické metody a hmotnostní spektrometrie.
Plasma proteins comprise a large group of different proteins. They can by dividend into 5 groups: alpha1 globulins, alpha2 globulins, beta globulins and gamma globulins. Separating serum proteins by electrophoresis is a valuable diagnostic tool. For the quantification of these proteins are used immunochemical methods and mass spectrometry.
- Keywords
- imunochemické metody, β-globuliny, α2-globuliny, α1-globuliny, plasmatické proteiny,
- MeSH
- Albumins MeSH
- Alpha-Globulins * analysis MeSH
- Beta-Globulins analysis MeSH
- Electrophoresis methods utilization MeSH
- Mass Spectrometry methods utilization MeSH
- Immunoglobulins * analysis MeSH
- Immunologic Techniques methods utilization MeSH
- Nephelometry and Turbidimetry methods utilization MeSH
- Serum Globulins * analysis MeSH
- MeSH
- Albuminuria diagnosis urine MeSH
- Algorithms MeSH
- Diabetic Nephropathies diagnosis urine MeSH
- Electrophoresis, Agar Gel methods MeSH
- Electrophoresis methods utilization MeSH
- Hematuria diagnosis urine MeSH
- Immunochemistry methods standards MeSH
- Clinical Laboratory Techniques methods standards MeSH
- Creatinine analysis urine MeSH
- Humans MeSH
- Nephelometry and Turbidimetry methods utilization MeSH
- Specimen Handling standards MeSH
- Predictive Value of Tests MeSH
- Proteinuria classification urine MeSH
- Check Tag
- Humans MeSH
- Publication type
- Practice Guideline MeSH
- MeSH
- Biomarkers blood urine MeSH
- Enzyme-Linked Immunosorbent Assay methods utilization MeSH
- Clinical Laboratory Techniques instrumentation MeSH
- Humans MeSH
- Lipocalins diagnostic use isolation & purification blood MeSH
- Nephelometry and Turbidimetry methods utilization MeSH
- Kidney Diseases diagnosis MeSH
- Reference Values MeSH
- Reference Standards MeSH
- Quality Control MeSH
- Check Tag
- Humans MeSH
Autoři předkládají rozbor pacientů ambulantně léčených pro průduškové astma se zaměřením na pacienty s těžkým perzistujícím astmatem. Diskutují zařazení pacientů do jednotlivých subfenotypů na základě podrobných anamnestických a základních neinvazivních laboratorních vyšetření, která je možno uskutečnit v běžné ambulantní praxi specializovaných ambulancí. Rozdělení do jednotlivých subfenotypů se v podstatě shoduje s rozčleněním do subfenotypů na základě časově náročných a často i invazivních laboratorních vyšetření na identifikaci typu zánětu v dýchacích cestách astmatiků.
Authors present an analysis of outpatients treated for asthma with a focus on patients with severe persistent asthma. Discusse the classification of patients into subfenotypes based on detailed anamnestic and basic non-invasive laboratory tests that may be made in classical clinical practice of specialized ambulances. Division into individual subfenotypes essentially coincides with the breakdown subfenotypes based on time-consuming and often invasive laboratory test to identify the type of airway inflammation in asthmatics.
- Keywords
- průduškové astma, subfenotypy astmatu,
- MeSH
- Allergens isolation & purification MeSH
- Hypersensitivity diagnosis etiology MeSH
- Biomedical Research methods MeSH
- Asthma diagnosis etiology therapy MeSH
- Eosinophilia diagnosis MeSH
- Phenotype MeSH
- Immunoglobulin E isolation & purification MeSH
- Comorbidity MeSH
- Skin Tests methods utilization MeSH
- Humans MeSH
- International Classification of Diseases standards utilization MeSH
- Nephelometry and Turbidimetry methods utilization MeSH
- Disease Progression MeSH
- Respiratory Hypersensitivity diagnosis etiology therapy MeSH
- Spirometry methods utilization MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
- MeSH
- Acrodermatitis etiology immunology metabolism MeSH
- Cell Nucleus immunology metabolism pathology MeSH
- Financing, Organized MeSH
- gamma-Globulins deficiency MeSH
- Immunologic Tests methods utilization MeSH
- Infant MeSH
- Humans MeSH
- Milk, Human chemistry immunology metabolism MeSH
- Nephelometry and Turbidimetry methods utilization MeSH
- Immune System Diseases diagnosis complications MeSH
- Diarrhea, Infantile etiology MeSH
- Flow Cytometry methods utilization MeSH
- Respiratory Burst drug effects MeSH
- Spectrophotometry methods utilization MeSH
- Cell Shape MeSH
- Zinc metabolism deficiency therapeutic use MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Apolipoproteins isolation & purification adverse effects MeSH
- Immunoglobulin M immunology drug effects MeSH
- Humans MeSH
- Cerebrospinal Fluid immunology MeSH
- Nephelometry and Turbidimetry methods utilization MeSH
- Nervous System Diseases prevention & control therapy MeSH
- Cerebrospinal Fluid Proteins isolation & purification adverse effects MeSH
- Check Tag
- Humans MeSH
- MeSH
- Butylamines chemistry MeSH
- X-Ray Diffraction methods instrumentation utilization MeSH
- DNA biosynthesis chemistry MeSH
- Financing, Organized MeSH
- Liposomes chemistry MeSH
- Nephelometry and Turbidimetry methods instrumentation utilization MeSH
- Surface-Active Agents chemistry MeSH
- Scattering, Radiation MeSH
- Synchrotrons instrumentation utilization MeSH
