Publikace se zaměřuje na možnosti radioterapie mycosis fungoides. Určeno odborné veřejnosti.; Mycosis fungoides je závažné maligní onemocnění s obtížnou diagnostikou i léčbou. Onemocnění postihuje nejčastěji kůži, časem však může progredovat i do vnitřních tkání a orgánů. Publikace si klade za cíl přispět ke zlepšení diagnostiky a terapie.

• MeSH
• mycosis fungoides radioterapie   MeSH
• radioterapie MeSH
• Publikační typ
• monografie MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• radiologie, nukleární medicína a zobrazovací metody
• onkologie
• dermatovenerologie

Publikace se zaměřuje na radiologickou fyziku, radioaktivitu a ionizující záření. určeno odborné veřejnosti.; Monografie zahrnuje všechny důležité oblasti radiologické fyziky, včetně jejího vývoje v historickém kontextu. Postupně probírá jednotlivé typy radioaktivní přeměny, jejich vlastnosti a základy interakcí ionizujícího záření s hmotou.

• MeSH
• fyzika MeSH
• ionizující záření MeSH
• radioaktivita MeSH
• radiologie MeSH
• Publikační typ
• monografie MeSH

• Konspekt
• Fyzikální stavba hmoty. Jaderná fyzika. Molekulární fyzika
• NLK Obory
• fyzika, biofyzika

• MeSH
• albuterol aplikace a dávkování   škodlivé účinky   MeSH
• aplikace inhalační MeSH
• bronchiální astma diagnóza   patologie   MeSH
• diferenciální diagnóza MeSH
• dítě * MeSH
• hormony kůry nadledvin aplikace a dávkování   MeSH
• hospitalizace MeSH
• inhalační nástavce MeSH
• lidé MeSH
• obstrukce dýchacích cest * diagnóza   farmakoterapie   klasifikace   patologie   MeSH
• směrnice pro lékařskou praxi jako téma MeSH
• Check Tag
• dítě * MeSH
• lidé MeSH
• Publikační typ
• přehledy MeSH

• MeSH
• bronchoalveolární laváž MeSH
• bronchoskopie MeSH
• chybná diagnóza MeSH
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• neúspěšná terapie MeSH
• spirometrie MeSH
• tracheomalacie * diagnóza   etiologie   patologie   terapie   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH
• přehledy MeSH

The purpose of supervision is to ensure that clients' needs are met and to monitor the effectiveness of therapeutic interventions and the therapeutic relationship. Cognitive behavioural therapy (CBT) supervision is the systematic cooperation of the supervisee with the supervisor, which aims at increasing the therapists' competencies when working with specific clients. The advantage of supervision is the possibility to shape and develop the therapist's practical skills through specific techniques. This paper aims to review currently available CBT supervision strategies that boost the development of therapists' skills and provide possible examples. Various techniques are discussed, including behavioural, cognitive, imagery and psychodrama methods that facilitate supervisors in enhancing therapists' skills. In addition, complementary approaches are discussed, such as role-playing, modelling, chaining, or imitation to present at a particular moment of the therapy, increase the insight into the client's perspective or the treatment itself, and search for an alternative approach to improve the therapeutic outcomes for the client. Overall, the article describes the supervisor's need to have a flexible variety of skills and know which learning methods might be most effective for boosting the supervisee's skill level and needs with a particular client.

• MeSH
• behaviorální terapie * výchova   MeSH
• klinické kompetence * MeSH
• kognitivně behaviorální terapie * metody   MeSH
• lidé MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

INTRODUCTION: The relationship between a poorly functioning thyroid gland and erectile dysfunction (hereinafter, "ED") has been demonstrated in many studies. If a man has thyroid problems, it can negatively affect his ability to achieve or maintain an erection. The thyroid gland produces hormones that affect metabolism and overall body function, including blood circulation. If the thyroid gland is not functioning properly, it can lead to blood circulation disorders, which can affect erectile function. There are also symptoms of thyroid disorders that can contribute to ED. Some of these symptoms include fatigue, depression, and anxiety, which can negatively affect a man's psychological side and affect his sexual performance. OBJECTIVES AND METHODS: In our article, we present a series of patients with ED who were treated in our department and found to have some form of thyroid dysfunction. RESULTS: After treatment for thyroid dysfunction and treatment with 5-phosphodiesterase inhibitors were implemented, erectile function improved in all patients ((Wilcoxon Signed Rank Test; Z = -4.55; p (2-tailed) < 0.001; n = 27) to the level of mild or no ED. Improvement occurred in men with hyper- and hypothyroidism. After one year of treatment, there was no difference between the two groups (t-test; t = 0.75; df = 0.25; p < 0.46). CONCLUSION: This study shows that screening for thyroid dysfunction should be performed in all men with ED and that treating thyroid dysfunction may be an effective way to improve erectile function in men with these health problems.

• MeSH
• dospělí MeSH
• erektilní dysfunkce * farmakoterapie   MeSH
• hypertyreóza * komplikace   farmakoterapie   MeSH
• hypotyreóza * farmakoterapie   komplikace   MeSH
• inhibitory fosfodiesterasy 5 * terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH

OBJECTIVES: To create a Czech version of the Labor Coping Scale (LCS) evaluation tool intended for midwives when caring for a woman with labor pain, to evaluate its psychometric properties and to find out the opinion on it in clinical practice. MATERIALS AND METHODS: Are use a combination of methods. By using repeated back translation, the Czech version of the LCS tool was created. It included an assessment of the tool's content validity index and a questionnaire survey determining the midwives' approach to labor pain (N = 419), supplemented by a focus group method (N = 16 midwives). RESULTS: A new evaluation tool for the management of labor pain was created - the Pain Coping Scale, which assesses the management of labor pain, not intensity, like previous evaluation scales. It is a tool that maps 5 areas on a scale of 0-10. CONCLUSION: As part of her work, a midwife should be able to adequately assess a woman's management of labor pain, using a suitable tool, to reveal the factors that influence the development and experience of labor pain, and then choose an appropriate strategy in the care of a woman with labor pain. A new LCS labor pain assessment tool could help with this in the Czech environment.

• MeSH
• adaptace psychologická fyziologie   MeSH
• babictví MeSH
• dospělí MeSH
• lidé MeSH
• měření bolesti * metody   MeSH
• porodní bolesti * diagnóza   psychologie   MeSH
• průzkumy a dotazníky MeSH
• psychometrie MeSH
• těhotenství MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

OBJECTIVE: The article presents the results of a research study on a patient after an ischemic cerebral stroke, as presented in a case study. The aim of the research was to determine the impact of combined therapy, utilizing long-term and intensive special pedagogical care, occupational therapy and psychology, on the development of the patient's motor and communication abilities. The contribution deals with the possibilities of development and support for individuals in childhood after experiencing the illness, with the potential correction of identified deficits from a multidisciplinary perspective. CASE REPORT: The case study highlights a patient at the age of 7.2 years, following an ischemic cerebral stroke during the post-hospitalization period. Based on the analysis of medical documentation, we have developed a therapy proposal that reflects the individual needs of the patient from the perspective of special pedagogy, occupational therapy and psychology, taking into account the patients of school age. CONCLUSION: The results of the research study indicate that when working with a patient after an ischemic cerebral stroke, regular collaboration of a multidisciplinary team, along with effective integration of the various components of comprehensive rehabilitation, is necessary. Furthermore, this case study serves as a poignant example of the efficacy of such integrated therapy approaches in addressing the complex needs of pediatric stroke survivors. It not only highlights the potential for substantial functional recovery but also emphasizes the essential role of ongoing collaboration among diverse healthcare professionals.

• MeSH
• cévní mozková příhoda terapie   psychologie   MeSH
• dítě MeSH
• ergoterapie * metody   MeSH
• ischemická cévní mozková příhoda terapie   rehabilitace   psychologie   MeSH
• kombinovaná terapie MeSH
• lidé MeSH
• rehabilitace po cévní mozkové příhodě * metody   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

Background: Prolonged Grief Disorder (PGD) has recently been included in both the ICD-11 and DSM-5-TR diagnostic manuals. Studying its prevalence and correlates across cultures is vital for more effective identification, treatment, and prevention.Objective: This study aimed to examine prevalence rates of ICD-11-based PGD, in a representative Slovakian sample in response to deaths of loved ones occurring during the previous year. Further aims were to examine the factor structure of PGD symptoms and correlates of summed PGD item scores and PGD 'caseness'.Method: Self-reported data on PGD, depression, anxiety, alcohol use, and descriptive characteristics were gathered from a representative sample of the Slovak population (N = 319).Results: Data were gathered from N = 1853 people; 319 participants (17.2%) reported a loss in the past year. The prevalence of probable PGD among these bereaved participants was 1.99% for recent losses (<6 months, n = 151) and 7.75% for more distant losses (6-12 months, n = 130). The most frequently endorsed symptoms included longing/yearning for the deceased, sadness, denial/unrealness, and difficulty accepting the death. PGD symptoms had a unitary factor structure which was consistent for subsamples bereaved 1-5 and 6-12 months. The severity of PGD varied with kinship. Depression and anxiety, but not alcohol misuse, were associated with PGD severity and PGD caseness.Conclusions: These findings underscore that a significant group of people develop PGD between 6-12 months following a loss. This emphasises the need for targeted psychological interventions.

• MeSH
• deprese epidemiologie   psychologie   MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mezinárodní klasifikace nemocí MeSH
• prevalence MeSH
• úzkost epidemiologie   psychologie   MeSH
• zármutek * MeSH
• ztráta blízké osoby * MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Slovenská republika MeSH

6-Nitrobenzo[b]thiophene 1,1-dioxide (Stattic) is a potent signal transducer and activator of the transcription 3 (STAT3) inhibitor developed originally for anticancer therapy. However, Stattic harbors several STAT3 inhibition-independent biological effects. To improve the properties of Stattic, we prepared a series of analogues derived from 6-aminobenzo[b]thiophene 1,1-dioxide, a compound directly obtained from the reduction of Stattic, that includes a methoxybenzylamino derivative (K2071) with optimized physicochemical characteristics, including the ability to cross the blood-brain barrier. Besides inhibiting the interleukin-6-stimulated activity of STAT3 mediated by tyrosine 705 phosphorylation, K2071 also showed cytotoxicity against a set of human glioblastoma-derived cell lines. In contrast to the core compound, a part of K2071 cytotoxicity reflected a STAT3 inhibition-independent block of mitotic progression in the prophase, affecting mitotic spindle formation, indicating that K2071 also acts as a mitotic poison. Compared to Stattic, K2071 was significantly less thiol-reactive. In addition, K2071 affected cell migration, suppressed cell proliferation in tumor spheroids, exerted cytotoxicity for glioblastoma temozolomide-induced senescent cells, and inhibited the secretion of the proinflammatory cytokine monocyte chemoattractant protein 1 (MCP-1) in senescent cells. Importantly, K2071 was well tolerated in mice, lacking manifestations of acute toxicity. The structure-activity relationship analysis of the K2071 molecule revealed the necessity of the para-substituted methoxyphenyl motif for antimitotic but not overall cytotoxic activity of its derivatives. Altogether, these results indicate that compound K2071 is a novel Stattic-derived STAT3 inhibitor and a mitotic poison with anticancer and senotherapeutic properties that is effective on glioblastoma cells and may be further developed as an agent for glioblastoma therapy.

• Publikační typ
• časopisecké články MeSH