Tranzitorní globální amnézie (TGA) je charakterizována náhlým vznikem těžké anterográdní amnézie a absencí dalších fokálních neurologických příznaků. I když je TGA většinou považována za monofázické onemocnění, recidivující průběh není raritní. Etiopatogeneze recidivujících případů nebyla většinou systematicky hodnocena. Cílem naší práce je posouzení výskytu a možných etiopatogenetických faktorů recidivující TGA. V průběhu pěti let bylo na naší klinice hospitalizováno 55 pa­cientů s TGA, z toho u čtyř (7,3 %) šlo o recidivující formu onemocnění. Jednotlivé případy prezentujeme formou kazuistik. Naše práce poukazuje na skutečnost, že výskyt recidivující TGA není vzácný a v našem souboru (7,3 %) odpovídá literárním údajům. Recidivy se mohou vyvinout v období několika měsíců až let od první ataky. Etiopatogeneze se zřejmě neliší od nerecidivujících forem TGA. Prokázali jsme možnou souvislost s migrénou a vaskulární příčinou kardioembolické geneze. U žádného z pa­cientů nebyla prokázána souvislost s epilepsií, anamnéza nepodporovala familiární výskyt.

Transient global amnesia (TGA) is characterized by sudden onset of severe anterograde amnesia and absence of other focal neurological deficits. Although TGA is usually considered as monophasic disease, recurrence is not rare. Etiopathogenesis of recurrent cases has not yet been systematically evaluated. The aim of our study is to evaluate occurrence and pathophysiological factors of recurrent TGA. Within five years, 55 patients with TGA were admitted to our clinic, four of which (7.3%) presented with the recurrent form. All recurrent cases are presented as case reports. Our series showed that the incidence of recurrent TGA is not rare and, in our group (7.3%), corresponds to the reported data. Relapses can develop within several months up to several years after the first attack. Etiopathogenesis is probably the same as in non-recurrent forms of TGA. We considered possible association with migraine and vascular cardiac embolic origin. We did not find any association with epilepsy and the patient histories did not support familial occurrence. Key words: memory – transient global amnesia – tran­sient ischemic attack – migraine The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.

• MeSH
• kardiovaskulární nemoci MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• migréna MeSH
• mozek krevní zásobení   MeSH
• recidiva MeSH
• senioři MeSH
• tranzitorní globální amnézie * diagnóza   etiologie   patofyziologie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH

BACKGROUND: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF). METHODS: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV1) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection. RESULTS: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV1 pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection. CONCLUSIONS: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.

• MeSH
• COVID-19 * patofyziologie   komplikace   epidemiologie   MeSH
• cystická fibróza * patofyziologie   komplikace   MeSH
• dospělí MeSH
• index tělesné hmotnosti MeSH
• lidé MeSH
• nutriční stav * MeSH
• respirační funkční testy metody   MeSH
• retrospektivní studie MeSH
• SARS-CoV-2 MeSH
• usilovný výdechový objem MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Koagulační testy k určení rizika krvácení se používají po desetiletí. Do poslední doby jsme však neměli k dispozici laboratorní test, který by nás óohl upozornit na riziko trombózy v zátěžových situacích. Takovým testem by mohl být ProC Global fy Dade Behring - funkční globální screeningový test pro stanovení antikoagulační kapacity systému proteinu C. Stanovení jsme prováděli u skupiny osob s trombofilií a fyziologické rozmezí jsme ověřili na kontrolní skupině. Citlivost testu na Leidenskou mutaci faktoru V (FVL) v našem souboru byla 96,15%. Citlivost na snížení aktivity proteinu C, resp. S pod 60 % byla 75 %, resp. 53,57 %. Celková citlivost na defekty v systému proteinu C byla 87,65 %. Test ProC Global má význam využívat jako screening na FVL v rizikových situacích (např. před rozsáhlými chirurgickými zákroky), nebo pokud je obtížněji dostupné genetické vyšetření. Citlivost na defekty proteinu C a hlavně proteinu S není dostatečná k tomu, aby se test využil jako diagnostický na tyto defekty u osob s trombofilií. Použití PCG v kombinaci se stanovením aktivity antitrombinu, koncentrace fibrinogenu a základního koagulačního vyšetření (aPTT, PT, počet trombocytů) pokrývá většinu v současnosti známých trombofilních hemostatických defektů.

Coagulation testy to assess the risk of haemorrhage have been used for decades. Till recently we did not possess however a laboratory test which will draw attention to the risk of thrombosis under stressful conditions. Such a test could be ProC® Global of Dade Boehring Co., a functional global screening test for assessment of the anticoagulant kapacity of the protein C system. The estimations esere made in a group of subjects with thrombophilia and the physiological range was tested in a control group. The sensitivity of the test for Leiden's mutation of the V factor (FVL) in the investigated group was 96.15%. The sensitivity for reduction of the activity of protein C and S resp. below 60% was 75% and 53.57% resp. The general sensitivity to defects in the protein C system was 87.65%. The ProC Global test is useful as a screening for FVL in risk situations (e.g. before major surgical operations) or if genetic examination is not readily available. Sensitivity to protein C, and in particular protein S, is not sufficient to use the test as a diagnostic test for these defects in subjects suffering from thrombophilia. The application of PCG in combination with assessment of antithrombin activity, the fibrinogen level and basic coagulation examinations (aPTT, PT, number of thrombocytes) covers the majority of thrombophilic haemostatic defects known at present.

• MeSH
• finanční podpora výzkumu jako téma MeSH
• lidé MeSH
• nedostatek proteinu C diagnóza   MeSH
• plošný screening metody   využití   MeSH
• trombofilie diagnóza   MeSH
• Check Tag
• lidé MeSH

Cíl studie: Vyhodnocení efektu a rizik vaginální rekonstrukce prolapsu pánevních orgánů (POP). Tento článek (závěrečná III. část studie) uvádí ostatní komplikace (tj. kromě vaginálních a urologických), změny sexuálních funkcí a kvality života. Typ studie: Klinická prospektivní nerandomizovaná studie s dvouletým follow-up. Název a sídlo pracoviště: Gynekologicko-porodnické oddělení Nemocnice Milosrdných bratří p.o., Brno. Metodika: Dvouleté sledování všech vagináních rekonstrukcí v období od 1. 3. 2012 do 28. 2. 2014. Z celkem 410 výkonů byla provedena u 113 žen "klasická" rekonstrukce (skupina NT - "natural tissue", medián věku 60, maximum prolapsu průměrně 1,12 cm pod hymen) a u 297 byl aplikován vaginální implantát (skupina TVM - "transvaginal mesh", medián věku 66, prolaps průměrně 2,93 cm pod hymen). Hodnocení stavu: předoperačně, v časném pooperačním období a za 2 - 6 - 12 a 24 měsíců. Pro tuto část studie jsme užili i dotazník na sexuální funkce - PISQ-12 a VAS (visual analogue scale) na stanovení míry uro-gynekologických obtíží. Výsledky: Komplikace podle Mezinárodní klasifikace ICS/IUGA: T1 (0-48 hodin): NT skupina - dvě ženy (1,77 %): jedna se srdeční arytmií a krvácením, druhá s krvácením k resutuře. TVM - devět žen (3,03 %): jednou arytmie a osmkrát hematom (bez operace). T2 (2 dny - 2 měsíce): NT - tři případy (2,65 %), a to dvakrát krvácení a jednou hematom. TVM - sedm případů (2,36 %): šestkrát hematom (čtyři s evakuací) a jednou zánětlivý stav se subileem. Další komplikace byly jen ve skupině TVM: v kategorii gastrointestinální byly kromě ženy se subileem ještě tři pacientky s bolestmi konečníku (jednou evakuován absces), tj. celkem čtyři případy (1,35 %). Kožní a muskulo-skeletální komplikace třikrát (1,01 %) - bolesti s projekcí do dolní končetiny. T3 (2-12 měsíců): u čtyř žen (1,62 % z kontrol) bolesti v pánvi a dolní končetině. V období T4 (po 12 měsících) komplikace nebyly zaznamenány. Sexuální funkce podle PISQ-12: průměrné skóre vstupní - po roce - po dvou letech: NT skupina 13,7 -10,6 - 10,5. TVM skupina 12,5 - 9,8 - 10,7. Podíl žen s vita sexualis bez obtíží - s obtížemi - sexuálně neaktivních: NT skupina vstupně: 48,9 % - 8,9 % - 42,2 %, po 24 měsících 50,0 % - 0 % - 50,0 %. TVM skupina vstupně: 42,7 % - 6,0 % - 51,3 %, na konci follow-up 42,7 % - 0 % - 57,3 %. Kvalita života podle míry obtíží: průměrné skóre vstupní - po - po dvou letech: NT skupina 58,0 - 18,7 - 16,0. TVM skupina 61,0 -10,0 - 11,0. Závěr: Vaginální rekonstrukce prolapsu měly v našem souboru malé množství komplikací, skóre PISQ (sexuální funkce) se v obou podskupinách zlepšilo, podíl žen s bezproblémovým vita sexualis zůstal stejný. Kvalita života se podle subjektivní míry obtíží razantně zlepšila, a to markantněji ve skupině s implantátem.

Objective: To evaluate the effect, the risks and benefits of vaginal reconstruction surgery for pelvic organ prolapse (POP). This article, being the last part of a study, focuses on complications (except for vaginal and urological ones), sexual function and the quality of life. Design: Clinical prospective non-randomized trial, two years follow-up. Setting: Obstetrics and Gynecology Department, Merciful Brothers Hospital, Brno. Materials and methods: All women who underwent anterior and/or posterior vaginal repair in our hospital in the period from 1. 3. 2012 to 28. 2. 2014 were involved in the study. From among the total (410 surgeries), 297 women received transvaginal mesh (TVM group: median of age: 66, the most prolapsed point average being +2,93 cm), 113 women underwent "native tissue reconstruction" NT group (median of age: 60, average of prolapse +1,12 cm). The status was evaluated preoperatively, in the early postoperative period and 2 - 6 - 12 and 24 months after the surgery. Results: Complications according to the International ICS/IUGA classification: T1 (0 -48 hours): two women in NT group (1.77%) - one with arythmia and bleeding, the second with bleeding needed suture. The TVM group registered 9 irregularities (3.03%) - one case of arythmia and eight cases of haematoma (solved conservatively). During the T2 period (from two days to two months) three irregularities - 2.65% - were found in the NT group (two bleeding and one haematoma case). After TVM there were seven "patient compromise" events (2.36%): six times haematoma (four times evacuated) and one inflammatory state plus subileus. In the gastrointestinal category four women (1.35%) - one already mentioned above and three indicating anorectal pain (one due to abscess - evacuated). The skin and/or musculoskeletal category comprised three cases (1.01%) of pelvic/leg pain. No case falling in the two last mentioned categories, and in the rest of the follow-up cohort, either, was registered in the NT group. The period 2 -12 months (T3): four women (1.62% of those appearing for control) mentioned pelvic/leg pain, but none in the last period did (T4 - over 12 months). The sexual functioning according to the PISQ -12 questionnaire: the average score, indicating the condition before the surgery and then at 12 and 24 months, was 13.7 - 10.6 - 10.5 in the NT group. The TVM group results indicate the respective scores at the level of 12.5 - 9.8 - 10.7. The quality of sexual life, namely the percentage of smooth - impaired - none reported by the NT group women of 48.9 - 8.9 - 42.2 at the beginning, whereas 50.0 - 0 - 50.0 after 24 months. The TVM procedure resulted in the analogous percentages of 42.7 - 6.0 - 51.3 to start with, whereas 42.7 - 0 - 57.3 at the end. The quality of life was measured by way of VAS (visual analogue scale 0 -100 points): women marked the point corresponding with their subjective bother in uro/gynaecological domain. The average score before the surgery, after 12 and 24 months, respectively, amounted to 58.0 - 18.7 - 16.0 in the NT group and to 61.0 - 10.0 - 11.0 in the TVM group. Conclusion: The number of complications induced by the vaginal reconstructive procedures is shown to be low in the light of our survey. The PISQ score (sexual function) improved in both groups (NT and TVM) and the percentage of women with unimpaired sexual life before and after the surgery is seen to be equal. The quality of life according to the subjective bother improved markedly in both groups, the difference in the TVM group being even more distinctive.

• Klíčová slova
• plastika poševní, vaginální síťka, sexuální funkce,
• MeSH
• dospělí MeSH
• gynekologické chirurgické výkony metody   MeSH
• klinická studie jako téma MeSH
• kvalita života MeSH
• lidé středního věku MeSH
• lidé MeSH
• pooperační komplikace * MeSH
• prolaps pánevních orgánů * chirurgie   MeSH
• průzkumy a dotazníky MeSH
• senioři MeSH
• zákroky plastické chirurgie * metody   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH

• MeSH
• amnézie etiologie   MeSH
• mapování mozku MeSH
• mozek patofyziologie   MeSH
• poranění mozku MeSH
• Publikační typ
• kazuistiky MeSH

The evolutionary and environmental factors that shape fungal biogeography are incompletely understood. Here, we assemble a large dataset consisting of previously generated mycobiome data linked to specific geographical locations across the world. We use this dataset to describe the distribution of fungal taxa and to look for correlations with different environmental factors such as climate, soil and vegetation variables. Our meta-study identifies climate as an important driver of different aspects of fungal biogeography, including the global distribution of common fungi as well as the composition and diversity of fungal communities. In our analysis, fungal diversity is concentrated at high latitudes, in contrast with the opposite pattern previously shown for plants and other organisms. Mycorrhizal fungi appear to have narrower climatic tolerances than pathogenic fungi. We speculate that climate change could affect ecosystem functioning because of the narrow climatic tolerances of key fungal taxa.

• MeSH
• biodiverzita MeSH
• déšť MeSH
• druhová specificita MeSH
• fylogeografie MeSH
• houby fyziologie   MeSH
• internacionalita * MeSH
• podnebí * MeSH
• teplota MeSH
• Publikační typ
• časopisecké články MeSH
• metaanalýza MeSH
• práce podpořená grantem MeSH

The objective of this study was to evaluate the effects of Valsartan (Valsacor®) on arterial pressure (AP) and indices of myocardial diastolic and global function in patients with uncontrolled arterial hypertension (AH). Material and methods: 60 patients (39 men and 21 women, mean age 63.9 ± 10.8 years, P > 140/90 mmHg with a background of combined antihypertensive therapy) were involved in the study. Valsartan (Valsacor®) was added to the standard therapy. The follow-up continued for three months, with clinical visits at initiation and completion of the study. The echocardiographic (EchoCG) evaluation included measurements of left ventricular and left atrial dimensions and function via longitudinal strain and Doppler-analysis of the transmitral blood flow. Results: The administration of Valsartan (Valsacor®) ) resulted in a significant improvement in the antihypertensive control in the studied patients. The mean values of the baseline systolic blood (SBP) and diastolic blood (DBP) pressure in the studied group of patients were 174.9 ± 17.9 (range 150–230) mmHg and 97.5 ± 6.4 (range 85–110) mmHg, respectively. The mean SBP and DBP values at the end of the third month of the follow-up period were 139.1 ± 10.9 (range 120–180) mmHg and 84.9 ± 6.2 mmHg, respectively, at p < 0.05, compared to the baseline. The results of the echocardiographic analysis revealed significant differences in the dynamic performance of the indices: telesystolic dimension of the left ventricle, deceleration time (DT), E‘, E/E‘ ratio and values of longitudinal strain. The observed dynamic performance reflects favour­able responses of the indices for diastolic function and longitudinal strain in the studied patients. Conclusion: Valsartan (Valsacor®), used as an adjunct to the standard antihypertensive therapy in patients with insufficiently controlled AH, leads to optimisation of the AP values and improvement of the indices of diastolic and global myocardial function, with a very good safety profile.

• MeSH
• antihypertenziva MeSH
• blokátory receptorů AT1 pro angiotensin II aplikace a dávkování   farmakologie   terapeutické užití   MeSH
• dospělí MeSH
• echokardiografie MeSH
• hemodynamika MeSH
• hodnocení léčiv MeSH
• hypertenze * farmakoterapie   patologie   MeSH
• krevní tlak * účinky léků   MeSH
• lidé středního věku MeSH
• lidé MeSH
• pulzní dopplerovská echokardiografie statistika a číselné údaje   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• tetrazoly MeSH
• valin * analogy a deriváty   terapeutické užití   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH

Malignant lymphoma survivors are at increased risk for anthracycline and/or radiotherapy-induced chronic cardiotoxicity. Proper long-term follow-up is essential for malignant lymphoma survivors after-care. This study aimed to assess TTE parameters of potential subclinical cardiotoxicity and to examine their utility in diagnosing chronic cardiotoxicity. Improvement of the diagnostic process may precede the manifestation of cardiac adverse events. Main objective of the study was to improve the identification of cancer survivors in increased risk of treatment cardiotoxicity. To achieve this goal, utility of various echocardiography parameters was examined.In this retrospective study we analysed TTE of 167 subjects with speckle tracking according to the European Society of Echocardiography guidelines during the follow-up period. 88 of them were long-term lymphoma survivors diagnosed with malignant lymphoma between the years 1994-2015. Minimum follow up period was 5 years with the median of 10 years after anti-cancer treatment cessation. TTE were performed between the years 2017-2022 at cardio-oncology outpatient office during regular follow-up period. A total of 79 volunteers with no history of chronic heart failure (CHF) or decline in LVEF, 51 (64.6%) of whom were males, with the median age of 46 (16-58) years were included in the analysis as control group. Control subjects had various indications for TTE (e.g. preoperative examination, benign palpitations, or with well controlled arterial hypertension taking two antihypertensives at most). Ischemic heart disease was ruled out by stress test. None of the control subjects had history of stroke or chronic lower limb ischemia. All control subjects were considered clinically stable with no sign of cardiac impairment caused by primary disease. Both cancer survivors and control group were divided into subgroups based on LVEF: lower normal LVEF (53-61%), and higher normal LVEF (> 61%). Survivors with lower normal LVEF (53-61%) had a statistically significant decline in GLS compared to those with higher normal LVEF (> 61%). This phenomenon was not observed in control group indicating a possible additional diagnostic value of this parameter. Inclusion of GLS assessment in follow-up TTE examination of subjects with lower normal LVEF may improve the sensitivity of detection of chronic cardiotoxicity. Patients with declined GLS and lower normal LVEF are candidates for intensified follow-up to precede manifestation of cardiac adverse events.

• MeSH
• antracykliny škodlivé účinky   MeSH
• dospělí MeSH
• echokardiografie * MeSH
• funkce levé komory srdeční účinky léků   MeSH
• globální longitudinální strain MeSH
• kardiotoxicita * etiologie   diagnóza   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lymfom * farmakoterapie   MeSH
• mladiství MeSH
• mladý dospělý MeSH
• následné studie MeSH
• přežívající onkologičtí pacienti * MeSH
• retrospektivní studie MeSH
• tepový objem účinky léků   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

The relationship between negative attitudes and psychopathology is not yet clear. The current shift to a dimensional approach to mental disorders, as reflected in both the DSM-5 and ICD-11 models of personality disorders, seems to enrich the traditional approach to study attitudes. This study investigates whether and how impairments in personality functioning are linked to attitudes toward minorities. A comparison of levels of impairment in global and Self and interpersonal personality functioning, negative attitudes, social distance, and racism was conducted in the sample of 127 adults from the general population group (n = 69) and a group of people with diagnosed personality disorders (n = 58). Differences between both groups were found. The personality disorders group showed higher impairment in personality functioning, scored higher on negative attitude measures, and was more prone to the blatant expression of attitudes than the general population. The association between attitudes and personality functioning did not fully reflect these trends. However, given the nature of differences, it is suspected that the proclivity to the blatant expression of negative attitudes could go beyond negative attitudes toward minorities themselves and reflect disorder-related characteristics, that is, more problematic and conflicted relationships with others in general.

• MeSH
• Diagnostický a statistický manuál mentálních poruch MeSH
• dospělí MeSH
• etnické a rasové minority * MeSH
• lidé MeSH
• osobnost * MeSH
• poruchy osobnosti diagnóza   MeSH
• postoj MeSH
• psychopatologie MeSH
• rasismus MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

In spring of 2012, students and staff at the First Faculty of Medicine at Charles University in Prague invited distinguished public health stakeholders and experts to engage in a Global Health Forum. The forum lasted an afternoon, was academically and clinically engaging and offered students and medical faculty a venue to discuss the most pressing global public health concerns. Main outcomes from the forum included describing outstanding public issues in public health policy and prevention, infectious disease and public health systems raised by the speakers, stakeholders and attendees. One major result of this forum is the establishment of the Prague Center for Global Health - an interdepartmental and interdisciplinary research collaborative to further the discussion and much needed field and academic research in global public health. The Prague Center for Global Health will include multiple international research centers and main function and results will include new courses at the university, publications based on best practices and research and a venue to learn, share and create in the academic space.

• MeSH
• celosvětové zdraví * MeSH
• mezioborová komunikace MeSH
• Publikační typ
• kongresy MeSH