Aim: The aim of this study was to determine the relationship between nurses' sleep quality and body mass index. Design: This is a cross-sectional study. Methods: This study was conducted with 583 nurses working in a single hospital. It was conducted between July 2018 and June 2019. Results: Among the nurses participating in the study, 69.1% of nurses were found to have poor sleep quality. Body mass index was within normal range in 55.4% of nurses. Nurses working in intensive care unit / operation room / emergency units, nurses working for less than 10 years, nurses working on nights shifts have more normal body weights. There were statistically significant differences between body mass index ratios and sleep quality scores. Conclusion: Sleep quality was found to be negatively affected as working hours increased. In addition, a positive correlation was observed between sleep quality and BMI. Sleep quality increased as BMI increased.

• MeSH
• Body Mass Index * MeSH
• Humans MeSH
• Nutritional Status MeSH
• Sleep Wake Disorders MeSH
• Cross-Sectional Studies MeSH
• Sleep * MeSH
• Nurses MeSH
• Check Tag
• Humans MeSH

Objective: The study aimed to determine the correlation between noninvasively ultrasonographically obtained cervical vessel indices and invasively measured central venous pressure in critically ill pediatric patients. Design: Prospective observational study. Setting: Department of pediatric intensive care, university hospital. Material and methods: 77 patients aged 0 to under 19 years with inserted central venous catheter and central venous pressure monitoring requiring admission to the department of intensive care medicine were included in the study. Both spontaneously ventilating patients and patients on artificial pulmonary ventilation, hemodynamically stable patients, and children with circulatory support with low-dose vasoactive agents were included in the study. Each continuous variable (ultrasonographic indices, age, height, weight, central venous pressure) was summarized by descriptive statistics, the distribution of variables was examined, and the correlation was quantified by Spearman correlation. The analysis was performed in the entire data set as well as in individual patient subgroups. Results: In the group of all measurements, the collapsibility index of the internal jugular vein in B mode (-0.58, p < 0.001), the collapsibility index of the internal jugular vein in M mode (-0.45, p <0.001), and the ratio of the internal jugular vein in 30- and 0-degree position (0.43, p < 0.001) had the highest correlation with central venous pressure. In the group of spontaneously ventilated patients, the highest correlation with central venous pressure was also found for the collapsibility index of internal jugular vein in B mode (-0.51, p < 0.001), and in patients on artificial pulmonary ventilation for the collapsibility index of internal jugular vein in B mode (- 0.55, p < 0.001) and the distensibility index of internal jugular vein in B mode (-0.55, p < 0.001). The correlation of the ratio of the internal jugular vein and common carotid artery with central venous pressure was low in all measurements group (0.25, p < 0.05), low in the spontaneously ventilated group (0.3, p < 0.05) and none in the artificially ventilated group (0.04). Conclusion: The results of the present study suggest that ultrasonographically obtained cervical vessel indices may provide a non-invasive, easily repeatable, bedside alternative to central venous pressure examination in the estimation of intravascular filling in critically ill pediatric patients.

• MeSH
• Carotid Artery, Common diagnostic imaging   pathology   MeSH
• Central Venous Pressure * MeSH
• Child MeSH
• Catheterization, Central Venous MeSH
• Infant MeSH
• Correlation of Data MeSH
• Neck * diagnostic imaging   pathology   MeSH
• Humans MeSH
• Adolescent MeSH
• Vascular Diseases diagnostic imaging   pathology   MeSH
• Statistics, Nonparametric MeSH
• Prospective Studies MeSH
• Health Status Indicators MeSH
• Ultrasonography methods   MeSH
• Check Tag
• Child MeSH
• Infant MeSH
• Humans MeSH
• Adolescent MeSH
• Publication type
• Clinical Study MeSH
• Observational Study MeSH

Background: The main aim of the study was to explore the association between objectively measured physical fitness and the level of pain intensity. Methods: In this cross-sectional study, we included 1036 adolescents (mage ± SD = 16.3 ± 1.1 years; mheight ± SD = 1.74 ± 0.1 m; mweight ± SD = 64.7 ± 12.4 kg; mbody-mass index ± SD = 21.3 ± 3.0 kg/m2) from 11 secondary schools located in the city of Zagreb (Croatia). Physical fitness was determined by using waist circumference, sit-ups in 1 min, standing long jump and sit-and-reach tests. Overall physical fitness index was calculated by summing the z-score values of each physical fitness test. The level of pain intensity was assessed with the Numeric Pain Rating Scale, a one-dimensional measure of pain intensity. Associations were calculated with correlation analyses. Results: In boys, pain intensity was associated with sit-ups in 1 min (r = -0.16, p < 0.001), standing long jump (r = -0.14, p = 0.003) and overall physical fitness index (r = -0.13, p = 0.004), while no significant associations with waist circumference (r = 0.04, p = 0.438) and sit-and-reach test (r = -0.01, p = 0.822) were observed. In girls, pain intensity was associated with standing long jump (r = -0.17, p < 0.001) and overall physical fitness index (r = -0.10, p = 0.018), while no significant associations with waist circumference (r = 0.01, p = 0.735), sit-ups in 1 min (r = -0.06, p = 0.126) and sit-and-reach test (r = -0.05, p = 0.232) were observed. When we adjusted for self-rated health, sleep duration, smoking status, alcohol consumption, screen-time and psychological distress, similar associations remained. Conclusions: Our study shows a weak association between physical fitness and pain intensity in a large sample of adolescents. Although a cross-sectional design, health-professionals should use physical fitness as a screening tool to assess the level of pain intensity.

• MeSH
• Exercise MeSH
• Child MeSH
• Body Mass Index MeSH
• Humans MeSH
• Pain Measurement * MeSH
• Adolescent MeSH
• Waist Circumference MeSH
• Cross-Sectional Studies MeSH
• School Health Services * MeSH
• Body Weight MeSH
• Physical Fitness * MeSH
• Cities MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Croatia MeSH
• Cities MeSH

OBJECTIVE: In obese patients, we hypothesized physical exercise (PE) to affect lipids through its intrahepatic fat accumulation-lowering effect, associated with a decrease of total body fat (Fat%) and even weight (Mass). Design and setting: Thirty seven sedentary, non-diabetic women (BMI median 34.8) from our out-patient department were tested. Elimination criteria: recent weight reduction, lipid-influencing or heart rate-modifying medication. Participants: 50 entering, 37 finishing, 7 excluded for processing failure, 6 did not fulfill the protocol. INTERVENTIONS: PE protocol: 60 min supervised trainings, intensity at 65% of VO2max, modified by the clamp heart rate test. Median of total training hours was 34 during 115 days (median). Main Outcome Measurements: an effect of PE on total cholesterol (CH), triglycerides (TG), HDL-cholesterol (HDL_C), LDL-cholesterol (LDL_C), index of atherogenity (IA), atherogenic index of plasma (AIP), maximum peak oxygen consumption (VO2max), Mass, body mass index (BMI), waist circumference (Waist) and Fat%. RESULTS: Statistically significant differences at start (_s) and the end (_e) of PE (p<0.05): AIP -0.049, Mass -3.6 (kg), BMI -1.7 (kg/m2), Waist -2.5 (cm), Fat% -2.5, VO2max 2.92 (L.min-1kg-1). Correlation coefficients, Pearson's between Gaussian distributed (Gd-v) variables and Spearman ́s (non Gd-v) statistically significant (p<0.05): IA and BMI, IA and Mass, IA and Waist, IA and Fat%, LDL and BMI, LDL and Mass, LDL and Fat%, LDL and Waist, IA and VO2max, LDL_C and VO2max. CONCLUSIONS: PE improves lipid profile towards production of antiatherogenic particles more likely due to changes in anthropometric parameters than in improvement of physical fitness.

• MeSH
• Atherosclerosis metabolism   physiopathology   MeSH
• Exercise physiology   MeSH
• Adult MeSH
• Cholesterol, HDL blood   MeSH
• Body Mass Index MeSH
• Cholesterol, LDL blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Obesity metabolism   physiopathology   MeSH
• Sedentary Behavior MeSH
• Oxygen Consumption physiology   MeSH
• Physical Fitness physiology   MeSH
• Triglycerides blood   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

Úvod: Cílem studie bylo hodnocení významu Pneumonia Severity Index (PSI) pro predikci 30denní mortality pacientů s komunitní pneumonií (CAP) hospitalizovaných na jednotce intenzivní pneumologické péče (JIP). U pacientů byly hodnoceny komorbidity, komplikace, fyzikální, laboratorní, RTG a mikrobiologické nálezy a jejich vztah k prognóze nemocných. Pacienti a metody: Do studie bylo zařazeno 197 pacientů hospitalizovaných pro CAP na JIP Kliniky plicních nemocí a TBC LF UP a FN Olomouc v letech 2008–2012. U všech pacientů byla hodnocena riziková kritéria dle systému PSI. Výsledky: V celém souboru pacientů s CAP byla průměrná hodnota PSI 115,4 ? SD 30,4 bodů. Z celkového počtu 197 pacientů zemřelo 29 nemocných (14,7 %). Při srovnání skupin zemřelých a přeživších pacientů byly prokázány statisticky významné rozdíly v PSI (průměr ? SD: 137,4; 26,1 vs 111,7 ? 29,6 bodů; p < 0,0001), věku pacientů (průměr ? SD: 76,3 ? 12,9 vs 65,5 ? 14,7 let; p < 0,0001) a výskytu onemocnění srdce (86,2 % vs 67,3 %; p = 0,04) s nejvyšším podílem ICHS (58,6 % vs 38,7 %; p = 0,04). Dále při hodnocení fyzikálních a laboratorních nálezů byla prokázána u zemřelých pacientů oproti přeživším významně vyšší frekvence výskytu tachykardie nad 90/min (51,7 % vs 27,4 %; p = 0,01), tachypnoe > 30/min (37,9 % vs 13,7 %; p = 0,001) a acidózy s pH < 7,35 (27,6 % vs 8,9 %; p = 0,004). Korelační analýza neprokázala statisticky významnou závislost mezi PSI a délkou hospitalizace u přeživších pacientů. U pacientů s infekcí Staphylococcus sp. a Klebsiella pneumoniae byla zjištěna statisticky signifikantně delší doba hospitalizace. Hodnocení souvislosti ostatních sledovaných komorbidit, fyzikálních, laboratorních nálezů a patogenů s mortalitou neprokázalo významné rozdíly. Závěr: Naše studie prokázala, že PSI je významným prediktorem 30denní mortality pacientů s CAP na JIP, ale nekoreluje s délkou hospitalizace ani s nálezem jednotlivých patogenů. Nezávislými negativními prognostickými faktory u pacientů s CAP jsou věk, výskyt nemocí srdce (zejména ICHS), tachykardie, tachypnoe a acidóza. Výskyt infekce Staphylococcus sp. a Klebsiella pneumoniae se významně podílejí na prodloužení doby hospitalizace. Všechny tyto faktory mohou upozorňovat na potřebu zvýšené péče o pacienty s CAP.

Introduction: The aim of this study was to evaluate the prognostic value of Pneumonia Severity Index (PSI) for prediction of 30-day mortality in patients admitted to intensive care unit (ICU) for community-acquired pneumonia (CAP). In patients with CAP, comorbidities, complications, and physical, laboratory, radiological and microbiological findings were evaluated relative to their prognosis. Patient and methods: In the study, 197 patients with CAP, hospitalised at ICU of Department of Respiratory Medicine, University Hospital Olomouc between 2008 and 2012, were enrolled. Risk factors according to PSI were assessed in all patients. Results: In the studied cohort of patients with CAP, mean values of PSI were 115.4 ? SD 30.4 points. Overall, 29 patients (14.7 %) deceased. When comparing deceased and survived patients, statistically significant differences were found in PSI (mean ? SD: 137.4 ? 26.1 vs 111.7 ? 29.6 points, p < 0.0001), age (mean ? SD: 76.3 ? 12.9 vs 65.5 ? 14.7 years, p < 0.0001), incidence of heart diseases (86.2 % vs 67.3 %, p = 0.04) and ischaemic heart disease (58.6 % vs 38.7 %, p = 0.04). Assessment of physical and laboratory findings showed that deceased patients had significantly increased incidence of tachycardia above 90/min (51.7 % vs 27.4 %, p = 0.01), tachypnoe above 30/min (37.9 % vs 13.7 %, p = 0.001) and acidosis with pH < 7.35 (27.6 % vs 8.9 %, p = 0.004) comparing to survived patients. No significant correlation between PSI and the length of hospitalisation in survived patients was observed. In patients with Staphylococcus sp. and Klebsiella pneumoniae infection, longer hospitalisation period was observed. Comparison of other parameters such as comorbidities, physical and laboratory findings, and pathogens showed no significant differences when comparing deceased to survived patients. Conclusion: Our study showed that PSI represents an important predictor of 30-day mortality in patients with CAP at ICU, but does not correlate neither with the length of hospitalisation nor with particular pathogens. Independent negative prognostic factors in CAP were age, incidence of heart diseases (most importantly ischaemic heart disease), tachycardia, tachypnoe and acidosis. Staphylococcus sp. and Klebsiella pneumoniae infection led to longer hospitalisation period. All these factors point out the need for increased care in CAP patients.

• Keywords
• skórovací systémy,
• MeSH
• Acidosis complications   MeSH
• Length of Stay statistics & numerical data   MeSH
• Adult MeSH
• Risk Assessment * statistics & numerical data   MeSH
• Community-Acquired Infections diagnosis   complications   mortality   therapy   MeSH
• Myocardial Ischemia complications   MeSH
• Intensive Care Units MeSH
• Klebsiella pneumoniae isolation & purification   MeSH
• Comorbidity MeSH
• Middle Aged MeSH
• Humans MeSH
• Decision Support Techniques * MeSH
• Young Adult MeSH
• Pneumonia * diagnosis   complications   mortality   therapy   MeSH
• Prognosis MeSH
• Risk Factors MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Staphylococcus aureus isolation & purification   MeSH
• Statistics as Topic MeSH
• Severity of Illness Index * MeSH
• Tachycardia complications   MeSH
• Tachypnea complications   MeSH
• Age Factors MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

Tuky z mořských ryb a v nich obsažené omega3 polynenasycené dlouhořetězcové mastné kyseliny (EPA a DHA) mají zásadní vliv nejen na riziko srdečně cévních onemocnění, ale také na kognitivní funkce. Testovali jsme účinek do stravy přidaných 800 mg EPA a 1 200 mg DHA na den, obsažených v rybím oleji, na kognitivní funkce (memorování, koordinace a soustředění) intenzivně sportujících chlapců (N = 169, věk 10-15 let). Intervenovaná skupina konzumovala po dobu 6 měsíců 2 čajové lžičky oleje denně. Všichni chlapci denně zapisovali jídelníček a pravidelně podstupovali antropometrické analýzy pro vyloučení zásadních změn ve stravovacích a pohybových zvyklostech. Studii dokončilo celkem 121 chlapců (82 v intervenované a 39 v kontrolní skupině). Přidání definovaného množství EPA a DHA do stravy bylo verifikováno stanovením omega3 indexu z kapilární krve. Změny v omega3 indexu korelovaly s výsledky psychologického Bourdonova testu. Výsledky testu potvrdily statisticky významnou souvislost mezi hodnotou omega3 indexu s úrovní kognitivních funkcí mladých sportovců (zlepšení o 63 % v intervenované vs. o 43 % u kontrolní skupiny P = 0,0001; P = 0,007 po adjustaci na věk).

Omega3 long-chain fatty acids (EPA and DHA) from fish oil have a major impact not only on the risk of cardiovascular diseases but also on cognitive functions. We tested the effect of EPA and DHA contained in fish oil on cognitive functions (memorization, coordination, and concentration) in intensely sporting boys (N = 169, age 10-15 years). The group under intervention consumed 2 teaspoons of oil daily for 6 months. All boys regularly summarize the dietary intake questionnaire and underwent anthropometric analyzes to rule out major changes in eating and exercise habits. A total of 121 boys completed the study (82 in the intervention group and 39 in the control group). The change in the EPA and DHA in the diet was measured by determining the omega3 index from capillary blood. Changes in the omega3 index statistically significant relationship with the results of the psychological Bourdon test. The test results confirmed the correlation between the value of the omega3 index and the level of cognitive functions of soccer players (improvement by 63% in the intervention vs. by 43% in the control group P = 0.0001; P = 0.007 after age adjustment).

• Keywords
• Bourdonův test,
• MeSH
• Child MeSH
• Clinical Studies as Topic MeSH
• Cognition * MeSH
• Eicosapentaenoic Acid therapeutic use   MeSH
• Docosahexaenoic Acids therapeutic use   MeSH
• Humans MeSH
• Adolescent MeSH
• Fatty Acids, Omega-3 * therapeutic use   MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

OBJECTIVE: The objective of the study was to determine whether the bacterial load of genital mycoplasmas and gestation age are related to intraamniotic inflammatory response using the amniotic fluid levels of 18 inflammatory mediators. STUDY DESIGN: A prospective study of 145 women with singleton pregnancies complicated by preterm prelabor rupture of membranes between 24(0/7) and 36(6/7) weeks was conducted. Amniotic fluid was obtained from all women by transabdominal amniocentesis. The amounts of genital mycoplasma deoxyribonucleic acid were determined using the threshold cycle value and relative and absolute quantification techniques. A panel of multiple proteins was analyzed simultaneously using multiplex technology. RESULTS: Twenty-four women with the presence of genital mycoplasmas in amniotic fluid were included in the final analyses. The concentrations of 9 of the 18 evaluated proteins in the amniotic fluid correlated with bacterial load of genital mycoplasmas independent of the quantification technique used. CONCLUSION: The intensity of intraamniotic inflammatory response to genital mycoplasmas decreased with gestational age.

• MeSH
• Amniocentesis MeSH
• Bacterial Load MeSH
• Chorioamnionitis diagnosis   microbiology   MeSH
• DNA, Bacterial analysis   MeSH
• Adult MeSH
• Gestational Age MeSH
• Pregnancy Complications, Infectious diagnosis   microbiology   MeSH
• Humans MeSH
• Inflammation Mediators analysis   MeSH
• Young Adult MeSH
• Mycoplasma Infections diagnosis   MeSH
• Amniotic Fluid chemistry   microbiology   MeSH
• Fetal Membranes, Premature Rupture microbiology   MeSH
• Prospective Studies MeSH
• Severity of Illness Index MeSH
• Pregnancy MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Young Adult MeSH
• Pregnancy MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

The clinical course and therapy of mantle cell lymphoma (MCL) are heterogeneous and often unsatisfactory. Prognostic factors are needed to stratify the patients. Microvessel density (MVD) has prognostic significance in some malignancies. There is little information about the vasculature of MCL, although some antiangiogenic drugs are in use. We studied MVD using systematic uniform random sampling and unbiased counting frames in immunohistochemical reactions with anti-CD34 antibody in pre-therapeutic extramedullary MCL samples of 177 patients. We analyzed the relationship of MVD to overall survival (OS) and progression-free survival (PFS), as well as to proliferative activity (Ki-67), mantle cell lymphoma prognostic index (MIPI), morphological variant, pattern of growth, and localization. MVD varied widely: range 54.6-503.6 vessels/mm(2), median 158.2 vessels/mm(2). Higher MVD was associated with bone marrow infiltration at the time of diagnosis (P = 0.001). High MVD was associated with significantly worse OS (P = 0.04) only in patients treated with non-intensive (conventional) therapy. MVD correlated positively with MIPI scores but not with the proliferation, morphological variant, growth pattern, or localization. Univariate analysis identified a prognostic influence of morphological variant, MIPI, and proliferative activity on OS and PFS and a prognostic influence of bone marrow infiltration at the time of diagnosis on PFS. Multivariate analysis showed prognostic influence of MIPI and proliferative activity on OS and PFS only. In conclusion, this is the first clinicopathological study of MVD of MCL with long-term follow-up showing negative prognostic trends of high MVD in MCL and positive correlation of MVD and MIPI.

• MeSH
• Ki-67 Antigen analysis   MeSH
• Antigens, CD34 analysis   MeSH
• Combined Modality Therapy MeSH
• Humans MeSH
• Lymphoma, Mantle-Cell pathology   therapy   MeSH
• Microvessels pathology   physiology   MeSH
• Biomarkers, Tumor analysis   MeSH
• Disease-Free Survival MeSH
• Prognosis MeSH
• Cell Proliferation MeSH
• Retrospective Studies MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

Ztráta elasticity arteriální stěny provázená její zvýšenou tuhostí byla identifikována jako nezávislý prognostický faktor u pacientů s kardiovaskulárními chorobami. Standardním neinvazivním způsobem vyšetřování arteriální tuhosti je měření rychlosti pulzové vlny (pulse‑wave velocity – PWV), avšak jeho přesnost je ovlivněna změnami krevního tlaku (TK) v okamžiku měření. Protože mezi intravaskulárním tlakem a průměrem arterie existuje exponenciální vztah, lze definovat pomocí přirozeného logaritmu poměru systolického a diastolického tlaku a elasticity arteriální stěny tzv. parametr tuhosti tepenné stěny β. Parametr β je základem pro výpočet CAVI (Cardio‑Ankle Vascular Index), který je nezávislý na změnách TK. To představuje velkou výhodu CAVI, který byl v uplynulé dekádě předmětem intenzivního klinického výzkumu zaměřeného na hodnocení tuhosti tepen u pacientů s již existujícími kardiovaskulárními chorobami a také u osob se zvýšeným rizikem, např. s hypertenzí, diabetem nebo obezitou. Prvořadým cílem dia­gnostického využití CAVI je posouzení tepenné tuhosti a včasného záchytu aterosklerózy. CAVI je možné s úspěchem využít při monitorování případné progrese nemoci a také účinnosti nastavené léčby. Při konečném hodnocení CAVI se však doporučuje jistá opatrnost, neboť jeho zvýšené hodnoty odrážejí jak cévní tuhost vyvolanou patologickými mechanizmy v arteriální stěně, tak i stav zvýšeného tepenného napětí následkem kontrakce hladké svaloviny.

Loss of elasticity of the arterial wall accompanied by its stiffening has been identified as an independent prognostic factor in patients with cardiovascular dis­eases. The standard non‑invasive investigation of arterial stiffness is the measurement of pulse‑wave velocity (PWV), but its accuracy is affected by changes in blood pressure (BP) at the time of measurement. Because an exponential relationship exists between intravascular pressure and diameter of the artery, an arterial wall stiffness parameter β can be defined using the natural logarithm of the ratio of systolic and diastolic blood pressure and the elasticity of the arterial wall. Parameter β is the basis for the calculation of CAVI (Cardio‑Ankle Vascular Index), which is independent of changes in BP. This is a big advantage of CAVI, which has been the subject of intense clinical research in the past decade, focusing on the evaluation of arterial stiffness in patients with existing cardiovascular disease and also in patients at increased risk, such as those with hypertension, diabetes or obesity. The primary objective of the dia­gnostic use of CAVI is the assessment of arterial stiffness and early detection of atherosclerosis. CAVI can be successfully used for monitoring the possible progression of the disease and effectiveness of treatment. Nevertheless, it is recommended that the CAVI measurement is evaluated with some caution because its elevated values reflect vascular stiffness induced by pathological mechanisms in the arterial wall, as well as the increased arterial tension resulting from smooth muscle contractions.

• MeSH
• Pulse Wave Analysis utilization   MeSH
• Atherosclerosis prevention & control   MeSH
• Cardiovascular Diseases prevention & control   MeSH
• Humans MeSH
• Mathematics MeSH
• Vascular Diseases diagnosis   MeSH
• Coronary Artery Disease diagnosis   MeSH
• Prognosis MeSH
• Reference Standards MeSH
• Reproducibility of Results MeSH
• Risk Factors MeSH
• Vascular Stiffness * physiology   MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Female MeSH

BACKGROUND: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. METHODS: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. RESULTS: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). CONCLUSIONS: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

• MeSH
• Time Factors MeSH
• Adult MeSH
• Smoking adverse effects   epidemiology   pathology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Head and Neck Neoplasms epidemiology   etiology   MeSH
• Laryngeal Neoplasms epidemiology   etiology   MeSH
• Oropharyngeal Neoplasms epidemiology   etiology   MeSH
• Mouth Neoplasms epidemiology   etiology   MeSH
• Alcohol Drinking adverse effects   epidemiology   pathology   MeSH
• Risk Factors MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Case-Control Studies MeSH
• Severity of Illness Index MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Research Support, N.I.H., Extramural MeSH
• Research Support, N.I.H., Intramural MeSH