multivariate data analysis
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- MeSH
- nádory prsu prevence a kontrola MeSH
- plošný screening MeSH
- socialismus MeSH
- Geografické názvy
- historické zeměpisné názvy MeSH
... Statistics for Biology and Health -- Philip Hougaard -- Analysis of Multivariate Survival Data -- Survival ... ... Four different approaches to the analysis of such data are presented. ... ... This book is aimed at investigators who need to analyze multivariate survival data. ... ... It can be used as a textbook for a graduate course in multivariate survival data. ... ... censored data 7 -- 1.3.1 Diabetic nephropathy 8 -- 1.4 Multivariate data structures 9 -- 1.4.1 Parallel ...
Statistics for biology and health
1st ed. xvii, 542 s.
... Contents -- Preface xi -- 1 Introduction to Regression Modeling of Survival Data 1 -- 1.1 Introduction ... ... , 1 -- 1.2 Typical Censoring Mechanisms, 3 -- 1.3 Example Data Sets, 9 -- Exercises, 13 -- 2 Descriptive ... ... Methods for Survival Data 16 -- 2.1 Introduction, 16 -- 2.2 Estimating the Survival Function, 17 -- ... ... Regression Models for Survival Data 67 -- 3.1 Introduction, 67 -- 3.2 Semi-Parametric Regression Models ... ... Model, 208 -- 7.3 Time-Varying Covariates, 213 -- 7.4 Truncated, Left Censored and Interval Censored Data ...
Wiley series in probability and statistics
Second edition xiii, 392 stran : ilustrace, tabulky, grafy ; 24 cm.
- Konspekt
- Kombinatorika. Teorie grafů. Matematická statistika. Operační výzkum. Matematické modelování
- NLK Obory
- přírodní vědy
- NLK Publikační typ
- kolektivní monografie
- Klíčová slova
- bioinformatika, zdravotnická elektronická dokumentace, eHealth,
- MeSH
- databáze jako téma trendy využití MeSH
- financování organizované MeSH
- lidé MeSH
- medicína založená na důkazech MeSH
- metaanalýza jako téma MeSH
- molekulární biologie metody trendy MeSH
- nemocniční informační systémy trendy využití MeSH
- registrace MeSH
- sběr dat metody využití MeSH
- statistika jako téma MeSH
- systémy podporující rozhodování v léčbě trendy využití MeSH
- využití lékařské informatiky MeSH
- záznamy jako téma MeSH
- Check Tag
- lidé MeSH
A test-statistic typically employed in the gene set enrichment analysis (GSEA) prevents this method from being genuinely multivariate. In particular, this statistic is insensitive to changes in the correlation structure of the gene sets of interest. The present paper considers the utility of an alternative test-statistic in designing the confirmatory component of the GSEA. This statistic is based on a pertinent distance between joint distributions of expression levels of genes included in the set of interest. The null distribution of the proposed test-statistic, known as the multivariate N-statistic, is obtained by permuting group labels. Our simulation studies and analysis of biological data confirm the conjecture that the N-statistic is a much better choice for multivariate significance testing within the framework of the GSEA. We also discuss some other aspects of the GSEA paradigm and suggest new avenues for future research.
CONTEXT: Mucoadhesive oral films, with their prolonged residence time at the site of application, offer a promising approach for protection of the oral lesion surface. The addition of sodium hyaluronate of different molecular weights as a second mucoadhesive polymer into the film matrix could positively influence the physico-mechanical and mucoadhesive properties of films. OBJECTIVE: The aim of this study was to investigate the formulation of a monolayered film matrix containing varying amounts of sodium hyaluronate and to test the properties of such matrices by applying different characterization methods. MATERIALS AND METHODS: Film matrix was composed of two mucoadhesive polymers, carmellose sodium and sodium hyaluronate, plasticized with glycerol. Resulting films were characterized with regard to their viscosity and physico-mechanical properties. RESULTS AND DISCUSSION: Multivariate data analysis was employed to evaluate the influence of varying amounts of mucoadhesive polymers on the main mucoadhesive oral films' properties. The lower content of sodium hyaluronate caused improvements in mechanical properties and residence time on the artificial oral mucosa, both of which are the main characteristics that determine the quality of the final product. CONCLUSIONS: The best results were obtained by samples containing carmellose sodium with a small amount of sodium hyaluronate (about 0.5% in casting dispersion).
- MeSH
- adheziva chemie metabolismus MeSH
- adhezivita MeSH
- glycerol chemie metabolismus MeSH
- kyselina hyaluronová chemie metabolismus MeSH
- lékové transportní systémy metody MeSH
- lidé MeSH
- multivariační analýza MeSH
- orální absorpce MeSH
- pevnost v tahu MeSH
- polymery MeSH
- sodná sůl karboxymethylcelulosy chemie metabolismus MeSH
- ústní sliznice metabolismus MeSH
- uvolňování léčiv MeSH
- viskozita MeSH
- změkčovadla chemie metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Differences among lipidomic profiles of healthy volunteers, obese people and three groups of cardiovascular disease (CVD) patients are investigated with the goal to differentiate individual groups based on the multivariate data analysis (MDA) of lipidomic data from plasma, erythrocytes and lipoprotein fractions of more than 50 subjects. Hydrophilic interaction liquid chromatography on ultrahigh-performance liquid chromatography (HILIC-UHPLC) column coupled with electrospray ionization mass spectrometry (ESI-MS) is used for the quantitation of four classes of polar lipids (phosphatidylethanolamines, phosphatidylcholines, sphingomyelins and lysophosphatidylcholines), normal-phase UHPLC-atmospheric pressure chemical ionization MS (NP-UHPLC/APCI-MS) is applied for the quantitation of five classes of nonpolar lipids (cholesteryl esters, triacylglycerols, sterols, 1,3-diacylglycerols and 1,2-diacylglycerols) and the potential of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is tested for the fast screening of all lipids without a chromatographic separation. Obtained results are processed by unsupervised (principal component analysis) and supervised (orthogonal partial least squares) MDA approaches to highlight the largest differences among individual groups and to identify lipid molecules with the highest impact on the group differentiation.
- MeSH
- dospělí MeSH
- kardiovaskulární nemoci krev MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipidy krev chemie klasifikace MeSH
- lipoproteiny krev chemie klasifikace MeSH
- metoda nejmenších čtverců MeSH
- multivariační analýza MeSH
- obezita MeSH
- spektrometrie hmotnostní - ionizace laserem za účasti matrice metody MeSH
- výpočetní biologie MeSH
- vysokoúčinná kapalinová chromatografie metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Springer series in statistics
2nd ed. 357 s.
