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E-kniha

Fast Facts: Digital Medicine : Measurement

Basel : S. Karger, 2020

96 stran : ilustrace, tabulky

Technology is changing how we practice medicine. Sensors and wearables are getting smaller and cheaper, and algorithms are becoming powerful enough to predict medical outcomes. Yet despite rapid advances, healthcare lags behind other industries in truly putting these technologies to use. A major barrier is the cross-disciplinary approach required to create digital tools, a process that requires knowledge from many people across a range of fields. 'Fast Facts: Digital Medicine – Measurement' aims to overcome that barrier, introducing the reader to core concepts and terms and facilitating dialogue. Contrasting 'clinical research' with routine 'clinical care', this short colorful book describes types of digital measurement and how to use and validate digital measures in different settings. And with the burgeoning development of digital medicine tools, the authors provide a timely overview of the security, ethical, regulatory and legal issues to be considered before a product can enter the market.Contents:• What is digital medicine? • Where does digital medicine fit? • Regulatory considerations• Ethical principles and our responsibilities• Ethics in practice• Security, data rights and governance• Digital biomarkers and clinical outcomes• Measurement in clinical trials• Verification and validation• The future of digital medicine

MeSH
individualizovaná medicína metody MeSH
lékařská informatika MeSH
monitorování fyziologických funkcí metody přístrojové vybavení trendy MeSH
počítačové metodologie MeSH
Publikační typ
příručky MeSH

NLK Obory
lékařská informatika

Článek

Flash Glucose Monitoring (FreeStyle Libre) u diabetiků 2. typu léčených inzulínem

Kazuistiky v diabetologii. 2019 ; 17 (1) : 24.

Kazuistiky diabetol.
ISSN 1214-231X
Medvik
Zdroj

Článek

Acute glycemic changes in brain and subcutaneous tissue measured by continuous glucose monitoring system in hereditary hypertriglyceridemic rat

Physiological research. 2018 ; 67 (1) : 127-131. [pub] 20171110

Physiol. Res. (Print)
ISSN 1802-9973
Medvik
Zdroj

Parallel glucose measurements in blood and other different tissues give us knowledge about dynamics of glycemia changes, which depend on vascularization, distribution space and local utilization by tissues. Such information is important for the understanding of glucose homeostasis and regulation. The aim of our study was to determine the time-lag between blood, brain, and adipose tissue during rapid glucose changes in a male hHTG rat (n=15). The CGMS sensor Guardian RT (Minimed/Medtronic, USA) was inserted into the brain and into the abdominal subcutaneous tissue. Fixed insulin and variable rate of glucose infusion was used to maintain euglycemia during sensor calibration period. At 0 min, 0.5 g/kg of bolus of glucose was administered, and at 50 min, 5 IU/kg of bolus of insulin was administered. Further glucose and insulin infusion was stopped at this time. The experiment was finished at 130 min and animals were euthanized. The time-shift between glycemia changes in blood, brain, and subcutaneous tissue was calculated by identification of the ideal correlation function. Moreover, the time to achieve 90 % of the maximum glucose excursion after intervention (T90) was measured to compare our data with the literature. The time-lag blood vs. brain and blood vs. subcutaneous tissue was 10 (10; 15) min and 15 (15; 25) min, respectively. The difference was statistically significant (P=0.01). T90 after glucose bolus in brain and subcutaneous tissue was 10 min (8.75; 15) and 15 min (13.75; 21.25), respectively. T90 after insulin bolus in brain and subcutaneous tissue was 10 min (10; 15) and 20 min (20; 27.5), respectively. To the contrary, with literature, our results showed earlier glucose level changes in brain in comparison with subcutaneous tissue after glucose and insulin boluses. Our results suggest that glucose dynamics is different within monitored tissues under rapid changing glucose level and we can expect similar behavior in humans. Improved knowledge about glucose distribution and dynamics is important for avoiding hypoglycemia.

MeSH
glykemický index fyziologie MeSH
hypertriglyceridemie krev diagnóza genetika MeSH
krevní glukóza metabolismus MeSH
krysa rodu rattus MeSH
monitorování fyziologických funkcí metody trendy MeSH
mozek metabolismus MeSH
potkani Wistar MeSH
subkutánní tkáň metabolismus MeSH
zvířata MeSH
Check Tag
krysa rodu rattus MeSH
mužské pohlaví MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH

Článek

Technologie v diabetologii

Kožnarová, Radomíra
Autor Autorita Centrum diabetologie IKEM, Praha

Medicína po promoci. 2018 ; 19 (1) : 20-24.

Med. promoci
ISSN 1212-9445
Medvik
Zdroj

Technologické novinky v diabetologii umožňují pacientům, aby co nejvíce přiblížili podávání inzulinu fyziologickým podmínkám. Propojení inzulinových pump a kontinuální monitorace glykemie vede ke zlepšení kompenzace diabetu a ke snížení rizika hypoglykemie, která je limitujícím faktorem léčby. Metoda měření glykemie Flash Glucose Monitoring přináší podobnou alternativu pro všechny ostatní pacienty včetně těch, kteří aplikují inzulin pery.

Technological novelties in diabetology allow patients to get the administration of insulin as close as possible to physiological conditions. Linking insulin pumps and continuous monitoring of blood glucose leads to improved diabetes control and reduced risk of hypoglycaemia, which is a limiting factor in treatment. Flash Glucose Monitoring Method provides a similar alternative for all other patients, including those who apply insulin with the insulin pen.