c-value
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Úvod: V etiopatogenezi ischemické cévní mozkové příhody (iCMP) hraje podstatnou roli ateroskleróza. Na jejím rozvoji má významný podíl chronický zánětlivý proces. Mezi ukazateli zánětu byl ultrasenzitivní C-reaktivní protein (hsCRP) uznán nezávislým rizikovým faktorem iktu, prediktorem horšího postižení, recidiv i dalších kardiovaskulárních postižení. Cílem studie bylo posouzení vlivu hsCRP na tíži iCMP v akutní fázi, vztahu k subtypům iCMP, ateroskleróze karotid a posouzení jeho možné prediktivní hodnoty. Soubor pacientů a metodika: Stanovení plazmatických hladin hsCRP bylo provedeno u 110 probandů (66 mužů a 44 žen, průměrného věku 61,5±9,9) v akutní fázi iCMP. Tíže příhody byla hodnocena podle kriterií NIHSS. Soubor byl rozdělen podle etiologie do 3 skupin (ikty aterotrombotické-AT, embolické arterio-arteriální-EA, kardioembolické-EK) a stupně aterosklerotického postižení karotid (≤30 %; 30-69 %; ≥70 %). Za 3 měsíce od akutní fáze onemocnění byl hsCRP vyšetřen u 78 probandů (44 mužů a 34 žen). Kontrolní skupinu (KS) tvořilo 58 zdravých osob (32 mužů a 26 žen, průměrného věku 57,1±9,9 let). Výsledky: Ve srovnání s KS byly zjištěny vyšší hodnoty hsCRP u: (1) probandů v akutní fázi (p<0,0001); (2) nemocných s NIHSS <10 (p=0,001) i NIHSS≥10 (p<0,0001); (3) subtypu iktu AT (p<0,0001), méně i EK (p=0,01) a EA (p=0,01); (4)stupňů karotických stenóz≤30 % (p=0,008), 30-69 % (p=0,004) i ≥70 % (p=0,001); (5) probandů za 3 měsíce (p<0,0001). Ve vztahu ke Glasgow Outcome Scale (GOS) nebyl zjištěn rozdíl. Závěr: Studie potvrdila souvislost vyšších hladin hsCRP v akutní fázi iCMP a tíže neurologického deficitu, jakož souvislost vyšších hladin hsCRP s aterosklerózou karotid.
Introduction: Atherosclerosis plays an essential role in the etiopathogenesis of ischemic cerebrovascular accident (iCVA). A chronic inflammatory process shares significantly in its development. Among the inflammation indices, ultrasensitive C-reactive protein (hsCRP) has been considered an independent risk factor of ictus, predictor of a more severe affection, relapses as well as other cardiovascular disorders. The research aimed at judging the effects of hsCRP on the severity of iCVA in the acute phase, the relation to the iCVA subtypes, atherosclerosis of carotid arteries, and its possible predictive value. A set of patients and methods: The plasma hsCRP levels were determined in 110 probands (66 men, 44 women, mean age 61.5 ± 9.9 years) in the acute phase of iCVA. The accident severity was evaluated according to NIHSS criteria. A set was divided, according to etiology, into three groups (atherothrombotic – AT, embolic arterio-arterial – EA, cardioembolic – EC ictuses) and according to the degree of atherosclerotic affection of carotid arteries (≤ 30 %, 30 – 69 %, ≥ 70 %). Three months after the acute phase of the disease hsCRP was examined in 78 probands (44 men, 34 women). A control set (CS) consisted of 58 healthy subjects (32 men, 26 women, mean age 57.1 ± 9.9 years). Results: If compared with CS, higher levels of hsCRP were revealed in: (1) probands in the acute phase (p < 0.0001), (2) patients with NIHS < 10 (p = 0.001) as well as NIHSS ≥ 10 (p < 0.0001), (3) subtype of AT ictus (p < 0.0001), less in EC (p = 0.01) and EA (p = 0.01), (4) degrees of carotid stenoses ≤ 30 % (p = 0.008), 30 – 69 % (p = 0.004) and ≥ 70 % (p = 0.001), (5) probands after three months (p < 0.0001). No difference was found with regard to the Glasgow Outcome Scale (GOS). Conclusion: The study has confirmed the connection of higher hsCRP levels in the acute phase of iCVA and severity of a neurological deficit as well as that of higher hsCRP levels and carotid artery atherosclerosis.
Since the 1990s, blood donors have been scanned for anti-hepatitis C virus (anti-HCV) antibodies, which can be defined by enzyme immunoassay as a screening test. In this population, false-reactive ratios have been high. Recently, some authors have aimed to find a cutoff value for anti-HCV different from those established by test manufacturers to predict HCV infection. In this study, 321 patients, after two repeating tests, had reactive results in s/co <10 titers on anti-HCV test. The patients were 29.6 % (n = 95) in women and 70.4 % (n = 226) in men. The patients were classified into three groups by Western blot (WB) results (PS, positive; NG, negative; and ID, indeterminate). The average anti-HCV titer of the whole group was 2.61 ± 1.96. Anti-HCV titers of subgroups were 2.43 ± 1.95 in NG, 4.93 ± 2.53 in PS, and 2.50 ± 1.65 in ID (p < 0.001). There was a significant difference between NG and PS and between PS and ID subgroups (p < 0.001). There was a positive correlation between WB and anti-HCV titers in all patients (r = 0.298, p < 0.001), in women (r = 0.282, p < 0.001), and in men (r = 0.337, p = 0.002). According to receiver operator characteristic curve analysis, the cutoff value of anti-HCV titer to predict hepatitis C infection was >2.61 s/co, with 74.1 % sensitivity and 71.6 % specificity (area under the curve, 0.820; 95 % confidence interval, 0.753 to 0.887). We suggest that an effective cutoff value for anti-HCV other than that established by the manufacturer cannot be assigned to predict hepatitis C infection for blood donors in low-prevalence areas.
- MeSH
- chronická hepatitida C diagnóza imunologie MeSH
- Hepacivirus imunologie MeSH
- hepatitida C - protilátky krev MeSH
- klinické laboratorní techniky metody normy MeSH
- lidé MeSH
- prediktivní hodnota testů MeSH
- senzitivita a specificita MeSH
- western blotting metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
BACKGROUND: We aimed to evaluate whether C-reactive protein(CRP)/ Albumin ratio (CAR) performed in the early postoperative period after total laryngectomy could be a predictive factor for the development of pharyngocutaneous fistula (PCF). METHODS: The files of patients with laryngeal squamous cell carcinoma who underwent total laryngectomy between January 2005 and January 2019 were retrospectively reviewed. Patients were divided into two groups: patients with PCF (PCF group) and without (Non-PCF group). CAR values and risk factors were compared between groups. RESULTS: The overall incidence of PCF was 23.2%. There was a statistically significant difference between the two groups in terms of CRP and CAR levels (p = 0.001). The CAR value of 27.05 (sensitivity = 75.0% , specificity 68.2%, area under curve (AUC) = 0.742, 95% confidence interval 0.616-0.868) was determined as a cutoff value to describe the development of fistula in the early postoperative period. In multiple linear regression analysis, there was an independent relationship between presence of PCF and previous RT and CAR value. CONCLUSIONS: CAR, performed in the early postoperative period, may be a new and useful marker for predicting PCF after total laryngectomy.
- MeSH
- C-reaktivní protein metabolismus MeSH
- dospělí MeSH
- kožní píštěl etiologie MeSH
- laryngektomie * MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory hrtanu chirurgie MeSH
- nemoci faryngu etiologie MeSH
- pooperační komplikace etiologie MeSH
- prediktivní hodnota testů MeSH
- retrospektivní studie MeSH
- senioři MeSH
- sérový albumin metabolismus MeSH
- spinocelulární karcinom chirurgie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-MET) ligand/receptor axis has been implicated in pathogenesis of malignant diseases including squamous cell carcinoma of the head and neck (SCCHN). Overexpression of c-MET has been reported as a common molecular abnormality in SCCHN, although its prognostic and predictive value remains to be validated. METHODS: We systematically searched literature for studies evaluating c-MET expression on immunohistochemistry in newly diagnosed, non-metastatic SCCHN. The c-MET expressing cases were classified into three categories according to predefined cut-off values for positivity. Our aim was to assess the prevalence of c-MET expression and its relationship with selected clinicopathological variables. RESULTS: Twenty-eight studies with 2019 cases were included. Relative frequencies of c-MET expression above cut-off levels I, II, and III were 81.8%, 63.8%, and 46.2%, respectively. Differences between these three values were statistically significant (p<1.0×10-6). Above cut-off level II, c-MET positivity was associated with worse overall survival (p=4.0×10-6), positive nodal status (p=1.0×10-4), higher disease stage (p=7.0×10-4), older age (p=2.1×10-3), disease recurrence (p=2.0×10-2), and primary tumour localization in the oral cavity (p=2.3×10-2). Above cut-off level III, c-MET positivity was associated with worse disease-free or progression-free survival (p=9.0×10-6), p16 negativity (p=2.4×10-4), worse overall survival (p=4.0×10-4), positive epidermal growth factor receptor (EGFR) status (p=7.2×10-4), and larger primary tumours (p=4.6×10-3). CONCLUSION: In SCCHN, immunohistochemical overexpression of c-MET above cut-off levels III and particularly II was associated with inferior survival outcomes and advanced disease. Moreover, it represents a promising predictive biomarker for c-MET targeting, yet the optimal scoring method remains to be defined.
- MeSH
- analýza přežití MeSH
- epitelo-mezenchymální tranzice MeSH
- imunohistochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory hlavy a krku genetika patologie patofyziologie MeSH
- prognóza MeSH
- protoonkogenní proteiny c-met genetika fyziologie MeSH
- spinocelulární karcinom genetika patologie patofyziologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Cutaneous mast cell tumours (MCT) are among the most frequent malignancies in dogs. Their clinical behaviour is highly variable and, with the exception of mutations in the c-kit gene, little is known about their genetic aetiology. The mutational status of the c-kit exons 8, 9 and 11, and exons 5-8 of the TP53 gene was analysed to find markers for molecular stratification of MCTs and predictors of clinical outcome. Mutations in the c-kit gene were detected in 19.5% (n = 8/41) samples and their presence was significantly associated with the high histopathological grade (P = 0.038). Mutations in the DNA binding domain of the TP53 gene were found in 14.6% (n = 6/41) of the analysed MCTs, and their frequency was similar in low and high grade MCTs (P > 0.05). TP53 mutations were not useful prognostic factors in this sample of canine cutaneous MCTs.
- MeSH
- frekvence genu MeSH
- kožní mastocytóza genetika patologie veterinární MeSH
- mutace * MeSH
- nádorový supresorový protein p53 genetika MeSH
- nádory kůže genetika patologie veterinární MeSH
- nemoci psů genetika patologie MeSH
- prognóza MeSH
- protoonkogenní proteiny c-kit genetika MeSH
- psi MeSH
- stupeň nádoru veterinární MeSH
- zvířata MeSH
- Check Tag
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- apendicitida diagnóza MeSH
- C-reaktivní protein analýza diagnostické užití MeSH
- dítě MeSH
- interleukin-6 analýza diagnostické užití MeSH
- lidé MeSH
- počet leukocytů využití MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- kongresy MeSH
