Vitiligo je častá, autoimunitně podmíněná ztráta pigmentu, která souvisí s omezením funk- ce nebo destrukcí melanocytů. V klinickém obrazu najdeme okrouhlá, oválná nebo nepravidelná bílá ložiska v úrovni okolní kůže, typicky kolem očí, na rukou, kolenou nebo genitálu. Vitiligo může doprovázet jiné autoimunitní choroby jako je Hashimotova thyreoiditida, diabetes mellitus a další
Vitiligo is a common autoimmune mediated loss of pigmentation that follows the involvement incl. destruction of melanocytes. The disease is characterized by rounded, oval or irregular white patches most frequently localized in periorbital area, hands, knees and genitals. Vitiligo could be associated with other autoimmune diseases such as Hashimoto thyroiditis, diabetes mellitus and other diseases.
Pityriasis lichenoides je kožní onemocnění dosud neobjasněné příčiny s neznámou incidencí, trvající měsíce až roky, postihující děti i dospělé. Podle průběhu a závažnosti histologických změn můžeme pityriasis lichenoides zjednodušeně rozdělit na akutní formu a formu chronickou. Často je však pozorován překryv klinického a histologického obrazu. Z léčebných metod je nejefektivnější fototerapie a/nebo dlouhodobá antibiotická léčba. Prognóza je příznivá i navzdory dlouhodobému průběhu. Výjimkou je velmi vzácná ulceronekrotická febrilní forma, která může být fatální.
Pityriasis Lichenoides in Children and Adolescents Pityriasis lichenoides is a skin disease of unknown etiology and unknown incidence. It appears in children and adults and spontaneously dissappears after months or years. The disorder has a spectrum of more acute clinical and histological manifestation and milder clinical and histological variants with more chronic course, but intermediate forms can occur. The most effective treatment is phototherapy and/or systemic antibiotics. The disease prognosis is favourable despite its chronic course. The possibly lethal ulceronecrotic febrile form is very rare.
- MeSH
- Diagnosis, Differential MeSH
- Child MeSH
- Phototherapy methods MeSH
- Histological Techniques MeSH
- Hypopigmentation etiology pathology therapy MeSH
- Humans MeSH
- Macrolides administration & dosage MeSH
- Adolescent MeSH
- Pityriasis Lichenoides * diagnosis physiopathology pathology therapy MeSH
- Prognosis MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Publication type
- Review MeSH
- Keywords
- ruxolitinib, pegunigalsidáza alfa, vadadustat, Ivosidenib, mirikizumab, ublituximab, thiosulfát sodný,
- MeSH
- alpha-Galactosidase therapeutic use MeSH
- Anemia drug therapy MeSH
- Fabry Disease drug therapy MeSH
- Interleukin Inhibitors therapeutic use MeSH
- Janus Kinase Inhibitors therapeutic use MeSH
- Prolyl-Hydroxylase Inhibitors therapeutic use MeSH
- Humans MeSH
- Mutant Proteins therapeutic use MeSH
- Leukemia, Myeloid drug therapy MeSH
- Ototoxicity drug therapy MeSH
- Multiple Sclerosis drug therapy MeSH
- Drug Approval * MeSH
- Thiosulfates therapeutic use MeSH
- Vitiligo drug therapy MeSH
- Check Tag
- Humans MeSH
- Geographicals
- Europe MeSH
- MeSH
- Albinism, Ocular classification pathology MeSH
- Aniridia etiology classification pathology therapy MeSH
- Choroideremia etiology pathology MeSH
- Eye Diseases, Hereditary etiology classification pathology MeSH
- Diagnosis, Differential MeSH
- Child MeSH
- Adrenal Cortex Hormones administration & dosage classification adverse effects MeSH
- Immunomodulating Agents administration & dosage classification adverse effects MeSH
- Humans MeSH
- Iris Neoplasms classification pathology therapy MeSH
- Uveal Diseases * etiology classification pathology congenital MeSH
- Uvea abnormalities anatomy & histology MeSH
- Uveitis diagnosis etiology drug therapy classification complications pathology MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Review MeSH
- MeSH
- Acitretin administration & dosage MeSH
- Bexarotene therapeutic use MeSH
- Diagnosis, Differential MeSH
- Exanthema etiology MeSH
- Dermatitis, Exfoliative etiology drug therapy pathology MeSH
- Photopheresis MeSH
- Histological Techniques MeSH
- Hypopigmentation etiology MeSH
- Interferon-alpha administration & dosage MeSH
- Drug Therapy, Combination MeSH
- Combined Modality Therapy MeSH
- Bone Marrow pathology MeSH
- Lymphoma, T-Cell, Cutaneous diagnosis drug therapy physiopathology pathology therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphadenopathy etiology MeSH
- Lymph Nodes pathology MeSH
- Lymphocytosis blood MeSH
- Treatment Failure MeSH
- Tomography, X-Ray Computed MeSH
- Disease Progression MeSH
- Pruritus etiology MeSH
- Flow Cytometry MeSH
- Recurrence MeSH
- Sezary Syndrome * diagnosis drug therapy blood physiopathology pathology therapy MeSH
- Severity of Illness Index MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
Exantémy patří k onemocněním, která se často vyskytují nejen v ordinaci dětského dermatologa, ale i alergologa či pediatra. V dětském věku se vyskytují hlavně exantémy parainfekční, které jsou spojené s probíhajícím infektem. Morfologické projevy bývají často podobné, přesto charakter eflorescencí, jejich lokalizace a propagace jsou důležité pro stanovení správné diagnózy. Článek podává přehled parainfekčních exantémů u dětí se zaměřením na morfologii kožních projevů.
Exanthemas are often seen not only at paediatric dermatologist, but also at allergologist or paediatrician. In childhood, there are mainly parainfectious rashes, which are associated with the ongoing infection. Skin appearance is often similar and so the character of lesions, their localisation and progression are important for a correct diagnosis. The article provides an overview of parainfectious exanthemas in children focused on the morphology of skin manifestations.
- MeSH
- Acrodermatitis virology MeSH
- COVID-19 physiopathology pathology MeSH
- Diagnosis, Differential MeSH
- Child MeSH
- Erythema Infectiosum MeSH
- Exanthema * etiology classification MeSH
- Exanthema Subitum diagnosis etiology MeSH
- Hypopigmentation virology MeSH
- Communicable Diseases classification MeSH
- Skin Manifestations MeSH
- Humans MeSH
- Scarlet Fever MeSH
- Measles MeSH
- Skin Diseases, Viral epidemiology classification MeSH
- Rubella MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Review MeSH
Vitiligo is the most common depigmentation disorder of the skin. Currently, its therapy focuses on the halting of the immune response and stimulation of the regenerative processes, leading to the restoration of normal melanocyte function. Platelet-rich plasma (PRP) represents a safe and cheap regenerative therapy option, as it delivers a wide spectrum of native growth factors, cytokines and other bioactive molecules. The aim of this study was to develop a simple delivery system to prolong the effects of the bioactive molecules released from platelets. The surface of electrospun and centrifugally spun poly-ε-caprolactone (PCL) fibrous scaffolds was functionalized with various concentrations of platelets; the influence of the morphology of the scaffolds and the concentration of the released platelet-derived bioactive molecules on melanocytes, was then assessed. An almost two-fold increase in the amount of the released bioactive molecules was detected on the centrifugally spun vs. electrospun scaffolds, and a sustained 14-day release of the bioactive molecules was demonstrated. A strong concentration-dependent response of melanocyte to the bioactive molecules was observed; higher concentrations of bioactive molecules resulted in improved metabolic activity and proliferation of melanocytes. This simple system improves melanocyte viability, offers on-site preparation and is suitable for prolonged topical PRP administration.
- MeSH
- Drug Delivery Systems * methods MeSH
- Humans MeSH
- Melanocytes MeSH
- Platelet-Rich Plasma * MeSH
- Vitiligo therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- MeSH
- Acanthosis Nigricans epidemiology etiology MeSH
- Addison Disease physiopathology pathology MeSH
- Diabetes Mellitus, Type 2 physiopathology MeSH
- Child MeSH
- Fibrous Dysplasia, Polyostotic physiopathology MeSH
- Hyperpigmentation MeSH
- Hypothyroidism physiopathology MeSH
- Keloid epidemiology MeSH
- Skin Manifestations * MeSH
- Humans MeSH
- Adolescent MeSH
- Endocrine System Diseases metabolism physiopathology MeSH
- Neurofibroma genetics MeSH
- Neurofibromatosis 1 genetics physiopathology MeSH
- LEOPARD Syndrome physiopathology pathology MeSH
- Turner Syndrome physiopathology MeSH
- Vitiligo MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Publication type
- Review MeSH
Protinádorová imunoterapie se stává standardem léčby ve stále se zvyšujícím počtu diagnóz. Vedle jejího prokázaného protinádorového účinku je již dnes známa řada jejích specifických nežádoucích účinků, jejichž společným jmenovatelem je imunitní podklad jejich vzniku. Předkládaný článek shrnuje nejčastější typy kožní toxicity imunoterapie, včetně hodnocení závažnosti podle nové verze CTCAE (Common Terminology Criteria for Adverse Events). V rámci managementu léčby je přihlédnuto k současným doporučením ESMO (European Society for Medical Oncology) a NCCN (National Comprehensive Cancer Network).
- MeSH
- Exanthema chemically induced drug therapy MeSH
- Adrenal Cortex Hormones administration & dosage MeSH
- Immunotherapy * adverse effects MeSH
- Skin Diseases * chemically induced drug therapy classification MeSH
- Humans MeSH
- Antibodies, Monoclonal adverse effects therapeutic use MeSH
- Neoplasms drug therapy MeSH
- Pruritus chemically induced drug therapy MeSH
- Severity of Illness Index MeSH
- Skin Diseases, Vesiculobullous chemically induced diagnosis MeSH
- Vitiligo chemically induced MeSH
- Check Tag
- Humans MeSH
